A common human skin tumour is caused by activating mutations in β-catenin

@article{Chan1999ACH,
  title={A common human skin tumour is caused by activating mutations in β-catenin},
  author={Edward H. P. Chan and Uri Gat and Jennifer Madison McNiff and Elaine Fuchs},
  journal={Nature Genetics},
  year={1999},
  volume={21},
  pages={410-413}
}
WNT signalling orchestrates a number of developmental programs. In response to this stimulus, cytoplasmic β-catenin (encoded by CTNNB1 ) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family. One of the target genes for β-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to cancer, particularly in the colon. Most colon cancers arise from mutations in the gene encoding adenomatous polyposis coli (APC), a protein… CONTINUE READING
62 Citations
32 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3

  • Y Miyoshi
  • Cancer Res
  • 1998

Similar Papers

Loading similar papers…