A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.

@article{Oertel2009ACH,
  title={A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.},
  author={Bruno Georg Oertel and Mattias Kettner and Klaus Scholich and Christoph Renn{\'e} and Bianca Roskam and Gerd Geisslinger and Peter Harald Schmidt and J{\"o}rn L{\"o}tsch},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 10},
  pages={6530-5}
}
The single nucleotide polymorphism 118A>G of the human micro-opioid receptor gene OPRM1, which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position 40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees in pain-processing brain regions. The most pronounced N40D effects were found in brain regions involved in the sensory processing of pain intensity. Using the mu-opioid receptor-specific agonist DAMGO, we analyzed the… CONTINUE READING