A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.

@article{Feng2004ACH,
  title={A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.},
  author={Yan Feng and Tianhua Niu and Houxun Xing and Xin Xu and Changzhong Chen and Shaojie Peng and Lihua Wang and Nan Laird and Xiping Xu},
  journal={American journal of human genetics},
  year={2004},
  volume={75 1},
  pages={
          112-21
        }
}
Nicotine is the major addictive substance in cigarettes, and genes involved in sensing nicotine are logical candidates for vulnerability to nicotine addiction. We studied six single-nucleotide polymorphisms (SNPs) in the CHRNA4 gene and four SNPs in the CHRNB2 gene with respect to nicotine dependence in a collection of 901 subjects (815 siblings and 86 parents) from 222 nuclear families with multiple nicotine-addicted siblings. The subjects were assessed for addiction by both the Fagerstrom… CONTINUE READING
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