A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

@article{Weedon2006ACH,
  title={A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.},
  author={M. N. Weedon and Vanessa J. Clark and Yudong Qian and Y Ben-Shlomo and Nicholas J. Timpson and Shah Ebrahim and Debbie A Lawlor and Marcus E. Pembrey and Susan M. Ring and Terence J. Wilkin and Linda D. Voss and Alison N Jeffery and Brad Metcalf and Luigi Ferrucci and Anna Maria Corsi and Anna Murray and David Melzer and Bridget A Knight and Bev Shields and George Davey Smith and Andrew T Hattersley and Anna Di Rienzo and Timothy M. Frayling},
  journal={American journal of human genetics},
  year={2006},
  volume={79 6},
  pages={991-1001}
}
Fasting glucose is associated with future risk of type 2 diabetes and ischemic heart disease and is tightly regulated despite considerable variation in quantity, type, and timing of food intake. In pregnancy, maternal fasting glucose concentration is an important determinant of offspring birth weight. The key determinant of fasting glucose is the enzyme glucokinase (GCK). Rare mutations of GCK cause fasting hyperglycemia and alter birth weight. The extent to which common variation of GCK… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

Similar Papers

Loading similar papers…