A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels.

@article{Forsberg2001ACF,
  title={A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels.},
  author={Lars Georg Forsberg and Louise Lyren{\"a}s and Ulf H de Faire and Ralf Morgenstern},
  journal={Free radical biology & medicine},
  year={2001},
  volume={30 5},
  pages={500-5}
}
Oxidative stress is implicated in disease and aging. In order to obtain molecular genetic tools that can be used to determine the potential impact of oxidative stress we examined the human catalase gene promoter for possible variation. Genomic DNA isolated from 10 individuals was screened for polymorphisms in the 5'-flanking region by direct sequence analysis of PCR products (nt -307 to -46 from the transcription start site). A common C/T polymorphism -262 base pairs from the transcription… CONTINUE READING
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