A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys.

@article{Juul2009ACD,
  title={A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys.},
  author={Anders Juul and Kaspar S\orensen and L Aksglaede and Inger Garn and Ewa Rajpert-De Meyts and Ingunn R. Hullstein and Peter Hemmersbach and Anne Marie Ottesen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 3},
  pages={1005-11}
}
BACKGROUND Testosterone (T) is excreted in urine as water-soluble glucuronidated and sulfated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys. STUDY DESIGN A clinical study of 116 healthy boys aged 8-19 yr. UGT2B17 genotyping was performed using quantitative PCR… CONTINUE READING