A common core structure for U3 small nucleolar RNAs.

  title={A common core structure for U3 small nucleolar RNAs.},
  author={Toinette Hartshorne and Nina Agabian},
  journal={Nucleic acids research},
  volume={22 16},
U3 nucleolar small RNA (snRNA) is involved in early processing of the primary rRNA transcript. A secondary structure model for the unusually small Trypanosoma brucei U3 snRNA was deduced by chemical modification and enzymatic cleavage of U3 snRNA in deproteinized and ribonucleoprotein (RNP) forms. Comprehensive alignment of U3 snRNAs from vertebrate, plant, fungal and protozoan species clearly delineated conserved and divergent features. The 5' domain of the T. brucei U3 snRNA appears to form… CONTINUE READING