A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification.

@article{Cenik2017ACC,
  title={A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification.},
  author={Can Cenik and H. Chua and Guramrit Singh and Abdalla Akef and M. Snyder and Alexander F Palazzo and M. Moore and F. P. Roth},
  journal={RNA},
  year={2017},
  volume={23 3},
  pages={
          270-283
        }
}
Introns are found in 5' untranslated regions (5'UTRs) for 35% of all human transcripts. These 5'UTR introns are not randomly distributed: Genes that encode secreted, membrane-bound and mitochondrial proteins are less likely to have them. Curiously, transcripts lacking 5'UTR introns tend to harbor specific RNA sequence elements in their early coding regions. To model and understand the connection between coding-region sequence and 5'UTR intron status, we developed a classifier that can predict 5… Expand
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