A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.

@article{Klimchenko2009ACB,
  title={A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.},
  author={Olena Klimchenko and Marcella Mori and Antonio Distefano and Thierry Langlois and Fr{\'e}d{\'e}ric Larbret and Yann L{\'e}cluse and Olivier F{\'e}raud and William Vainchenker and Francoise Norol and Najet Debili},
  journal={Blood},
  year={2009},
  volume={114 8},
  pages={1506-17}
}
The megakaryocytic (MK) and erythroid lineages are tightly associated during differentiation and are generated from a bipotent megakaryocyte-erythroid progenitor (MEP). In the mouse, a primitive MEP has been demonstrated in the yolk sac. In human, it is not known whether the primitive MK and erythroid lineages are generated from a common progenitor or independently. Using hematopoietic differentiation of human embryonic stem cells on the OP9 cell line, we identified a primitive MEP in a subset… CONTINUE READING
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