A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase.

@article{Bradbury1999ACB,
  title={A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase.},
  author={Peter Bradbury and Christopher J. Mann and Silvano K{\"o}chl and Timothy A. Anderson and Stuart Chester and John M. Hancock and Peter J Ritchie and Joanna S. Amey and Georgina B. Harrison and David G. Levitt and Leonard J. Banaszak and Julie Denise Scott and Carol C. Shoulders},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 5},
  pages={3159-64}
}
The assembly of triglyceride-rich lipoproteins requires the formation in the endoplasmic reticulum of a complex between apolipoprotein B (apoB), a microsomal triglyceride transfer protein (MTP), and protein disulfide isomerase (PDI). In the MTP complex, the amino-terminal region of MTP (residues 22-303) interacts with the amino-terminal region of apoB (residues 1-264). Here, we report the identification and characterization of a site on apoB between residues 512 and 721, which interacts with… CONTINUE READING