A common ancestry for BAP1 and Uch37 regulators

  title={A common ancestry for BAP1 and Uch37 regulators},
  author={Luis S{\'a}nchez-Pulido and Lesheng Kong and Chris P. Ponting},
  volume={28 15},
SUMMARY To reveal how the polycomb repressive-deubiquitinase (PR-DUB) complex controls substrate selection specificity, we undertook a detailed computational sequence analysis of its components: additional sex combs like 1 (ASXL1) and BRCA1-associated protein 1 (BAP1) proteins. This led to the discovery of two previously unrecognized domains in ASXL1: a forkhead (winged-helix) DNA-binding domain and a deubiquitinase adaptor domain shared with two regulators of ubiquitin carboxyl-terminal… CONTINUE READING