A common LRRK2 mutation in idiopathic Parkinson's disease.

@article{Gilks2005ACL,
  title={A common LRRK2 mutation in idiopathic Parkinson's disease.},
  author={William P. Gilks and Patrick M. Abou-Sleiman and Sonia Gandhi and Shushant Jain and Andrew A Singleton and A. J. Lees and Karen Shaw and Kailash P Bhatia and Vincenzo Bonifati and Niall Quinn and John Lynch and Daniel G. Healy and J. L. Holton and Tamas R Revesz and Nicholas Wood},
  journal={Lancet},
  year={2005},
  volume={365 9457},
  pages={415-6}
}
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant Parkinson's disease. Few mutations in this gene have been identified. We investigated the frequency of a common heterozygous mutation, 2877510 g-->A, which produces a glycine to serine aminoacid substitution at codon 2019 (Gly2019 ser), in idiopathic Parkinson's disease. We assessed 482 patients with the disorder, of whom 263 had pathologically confirmed disease, by direct sequencing for… CONTINUE READING
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