A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.

@article{Telesford2015ACS,
  title={A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.},
  author={Kiel M. Telesford and Wang Yan and Javier Ochoa-Rep{\'a}raz and Anudeep B. Pant and Christopher Kircher and M. Amala Christy and Sakhina Begum-Haque and Dennis L Kasper and Lloyd H. Kasper},
  journal={Gut microbes},
  year={2015},
  volume={6 4},
  pages={234-42}
}
Polysaccharide A (PSA) derived from the human commensal Bacteroides fragilis is a symbiosis factor that stimulates immunologic development within mammalian hosts. PSA rebalances skewed systemic T helper responses and promotes T regulatory cells (Tregs). However, PSA-mediated induction of Foxp3 in humans has not been reported. In mice, PSA-generated Foxp3(+) Tregs dampen Th17 activity thereby facilitating bacterial intestinal colonization while the increased presence and function of these… CONTINUE READING
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