A combined within-host and between-hosts modelling framework for the evolution of resistance to antimalarial drugs.

@article{Legros2016ACW,
  title={A combined within-host and between-hosts modelling framework for the evolution of resistance to antimalarial drugs.},
  author={Mathieu Legros and Sebastian Bonhoeffer},
  journal={Journal of the Royal Society, Interface},
  year={2016},
  volume={13 117}
}
The spread of drug resistance represents a significant challenge to many disease control efforts. The evolution of resistance is a complex process influenced by transmission dynamics between hosts as well as infection dynamics within these hosts. This study aims to investigate how these two processes combine to impact the evolution of resistance in malaria parasites. We introduce a stochastic modelling framework combining an epidemiological model of Plasmodium transmission and an explicit… CONTINUE READING
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