A combined transmembrane topology and signal peptide prediction method.

@article{Kll2004ACT,
  title={A combined transmembrane topology and signal peptide prediction method.},
  author={Lukas K{\"a}ll and Anders Krogh and Erik L. L. Sonnhammer},
  journal={Journal of molecular biology},
  year={2004},
  volume={338 5},
  pages={1027-36}
}
An inherent problem in transmembrane protein topology prediction and signal peptide prediction is the high similarity between the hydrophobic regions of a transmembrane helix and that of a signal peptide, leading to cross-reaction between the two types of predictions. To improve predictions further, it is therefore important to make a predictor that aims to… CONTINUE READING