A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson’s disease patients

Abstract

Levodopa is the reference treatment for Parkinson’s disease. However, after several years of treatment, dyskinesia may occur and strategies to overcome this side effect still need to be explored. We identified a unique population pharmacokinetic/pharmacodynamic model in Parkinson’s disease to investigate the relationship and dissociability of motor response… (More)
DOI: 10.1007/s00228-016-2034-0

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