A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro.

@article{Fahmi2008ACM,
  title={A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro.},
  author={Odette A. Fahmi and Tristan S. Maurer and Mary Kish and Edwin Jonathan Escobedo Cardenas and Sherri E Boldt and David Nettleton},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 8},
  pages={1698-708}
}
Although approaches to the prediction of drug-drug interactions (DDIs) arising via time-dependent inactivation have recently been developed, such approaches do not account for simple competitive inhibition or induction. Accordingly, these approaches do not provide accurate predictions of DDIs arising from simple competitive inhibition (e.g., ketoconazole) or induction of cytochromes P450 (e.g., phenytoin). In addition, methods that focus upon a single interaction mechanism are likely to yield… CONTINUE READING
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