A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells.

Abstract

Cellular responses to mechanical stimuli are influenced by the mechanical properties of cells and the surrounding tissue matrix. Cells exhibit viscoelastic behavior in response to an applied stress. This has been attributed to fluid flow-dependent and flow-independent mechanisms. However, the particular mechanism that controls the local time-dependent… (More)
DOI: 10.1007/s10237-016-0817-y

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Cite this paper

@article{Florea2017ACE, title={A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells.}, author={Cristina Florea and Petri Kalevi Tanska and Mika Esa Juhani Mononen and Chengjuan Qu and Mikko J. Lammi and Mikko S. Laasanen and Rami K. Korhonen}, journal={Biomechanics and modeling in mechanobiology}, year={2017}, volume={16 1}, pages={297-311} }