A combined comparative genomic hybridization and expression microarray analysis of gastric cancer reveals novel molecular subtypes.

@article{Tay2003ACC,
  title={A combined comparative genomic hybridization and expression microarray analysis of gastric cancer reveals novel molecular subtypes.},
  author={Su Ting Tay and Siew Hong Leong and Kun Yu and Amit Aggarwal and Soo Yong Tan and Chee How Lee and Keith K H Wong and Jaya Visvanathan and Dennis Sher Ee Lim and Wai Keong Wong and Khee Chee Soo and Oi Lian Kon and Patrick Y. Tan},
  journal={Cancer research},
  year={2003},
  volume={63 12},
  pages={
          3309-16
        }
}
Comparative genomic hybridization (CGH), microsatellite instability (MSI) assays, and expression microarrays were used to molecularly subclassify a common set of gastric tumor samples. We identified a number of novel genomic aberrations associated with gastric cancer and discovered that gastric tumors could be grouped by their expression profiles into three broad classes: "tumorigenic," "reactive," and "gastric-like." Patients with gastric-like tumors exhibited a significantly better overall… CONTINUE READING
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