A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats.

@article{Mann2000ACC,
  title={A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats.},
  author={S. T. W Mann and M M Yuschak and S J Amyes and P Aughton and James P Finn},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2000},
  volume={38 Suppl 2},
  pages={S71-89}
}
The chronic toxicity and potential carcinogenicity of sucralose was evaluated by exposing Sprague-Dawley rats to dietary concentrations of this low-calorie sweetener both in utero and for up to 104 weeks following parturition. The rats assigned to the toxicity phase of this investigation were administered diets containing either 0% (control), 0.3% (3000 ppm), 1.0% (10,000 ppm) or 3.0% (30,000 ppm) sucralose. Each treatment group comprised 30 male and 30 female rats, of which 15 males and 15… CONTINUE READING