A combined biomaterial and cellular approach for annulus fibrosus rupture repair.

  title={A combined biomaterial and cellular approach for annulus fibrosus rupture repair.},
  author={Tatiana Nataly Pirvu and S{\'e}bastien B. G. Blanquer and Lorin M Benneker and Dirk W Grijpma and Robert Geoff Richards and Mauro Alini and David Eglin and Sibylle Grad and Zhen Li},
Recurrent intervertebral disc (IVD) herniation and degenerative disc disease have been identified as the most important factors contributing to persistent pain and disability after surgical discectomy. An annulus fibrosus (AF) closure device that provides immediate closure of the AF rupture, restores disc height, reduces further disc degeneration and enhances self-repair capacities is an unmet clinical need. In this study, a poly(trimethylene carbonate) (PTMC) scaffold seeded with human bone… CONTINUE READING
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Effect of pore characteristics on mechanical properties and annulus fibrosus Cell seeding and proliferation in designed PTMC tissue engineering scaffolds

SBG Blanquer, SP Haimi, AA Poot, DW. Grijpma
Macromol Symp 2013;334: • 2013
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