A combinatorial polymer library approach yields insight into nonviral gene delivery.

@article{Green2008ACP,
  title={A combinatorial polymer library approach yields insight into nonviral gene delivery.},
  author={Jordan J Green and Robert Langer and Daniel G Anderson},
  journal={Accounts of chemical research},
  year={2008},
  volume={41 6},
  pages={
          749-59
        }
}
The potential of gene therapy to benefit human health is tremendous because almost all human diseases have a genetic component, from untreatable monogenic disorders to cancer and heart disease. Unfortunately, a method for gene therapy that is both effective and safe has remained elusive. It has been said that "there are only three problems in gene therapy - delivery, delivery, and delivery." (quote from I. M. Verma in Jaroff, L. TIME, 1999; Jan 11). This Account describes an alternative… CONTINUE READING
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Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus

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