A combinatorial library of lipid-like materials for delivery of RNAi therapeutics


The safe and effective delivery of RNA interference (RNAi) therapeutics remains an important challenge for clinical development. The diversity of current delivery materials remains limited, in part because of their slow, multi-step syntheses. Here we describe a new class of lipid-like delivery molecules, termed lipidoids, as delivery agents for RNAi… (More)
DOI: 10.1038/nbt1402


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