A combinatorial code for the interaction of alpha-synuclein with membranes.

  title={A combinatorial code for the interaction of alpha-synuclein with membranes.},
  author={Shin-ichiro Kubo and Venu M. Nemani and Robert J. Chalkley and Malcolm D. Anthony and Nobutaka Hattori and Yoshikuni Mizuno and Robert H Edwards and Doris L. Fortin},
  journal={The Journal of biological chemistry},
  volume={280 36},
Considerable genetic and pathological evidence has implicated the small, soluble protein alpha-synuclein in the pathogenesis of familial and sporadic forms of Parkinsons disease (PD). However, the precise role of alpha-synuclein in the disease process as well as its normal function remain poorly understood. We recently found that an interaction with lipid rafts is crucial for the normal, pre-synaptic localization of alpha-synuclein. To understand how alpha-synuclein interacts with lipid rafts… CONTINUE READING


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