A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery.

@article{Murphy1998ACA,
  title={A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery.},
  author={John Murphy and Toshihiko Uno and J. F. den Hamer and Fred E. Cohen and Varavani Dwarki and Ronald N. Zuckermann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 4},
  pages={1517-22}
}
A family of N-substituted glycine oligomers (peptoids) of defined length and sequence are shown to condense plasmid DNA into small particles, protect it from nuclease degradation, and efficiently mediate the transfection of several cell lines. The oligomers were discovered by screening a combinatorial library of cationic peptoids that varied in length, density of charge, side-chain shape, and hydrophobicity. Transfection activity and peptoid-DNA complex formation are shown to be highly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Solvent effects on the conformational preferences of model peptoids. MP2 study.

Journal of peptide science : an official publication of the European Peptide Society • 2014

Applying horizontal gene transfer phenomena to enhance non-viral gene therapy.

Journal of controlled release : official journal of the Controlled Release Society • 2013
View 1 Excerpt

References

Publications referenced by this paper.

Murphy et al

P. Armand, K. Kirshenbaum, +8 authors total protein content were measured 48 hr after transfec Biochemistry
Proc. Natl. Acad. Sci. USA 95 • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…