A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.

@article{Lou2008ACA,
  title={A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.},
  author={X Q Lou and Guo-Bo Chen and Lei Yan and Jennie Z Ma and Jamie E. Mangold and Jun Zhu and Robert C. Elston and Ming D. Li},
  journal={American journal of human genetics},
  year={2008},
  volume={83 4},
  pages={
          457-67
        }
}
Widespread multifactor interactions present a significant challenge in determining risk factors of complex diseases. Several combinatorial approaches, such as the multifactor dimensionality reduction (MDR) method, have emerged as a promising tool for better detecting gene-gene (G x G) and gene-environment (G x E) interactions. We recently developed a general combinatorial approach, namely the generalized multifactor dimensionality reduction (GMDR) method, which can entertain both qualitative… CONTINUE READING
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