A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1.

@article{Bicker2011ACA,
  title={A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1.},
  author={Kevin L Bicker and Obiamaka Obianyo and Heather L. Rust and Paul R Thompson},
  journal={Molecular bioSystems},
  year={2011},
  volume={7 1},
  pages={
          48-51
        }
}
The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1 inhibitor with enhanced selectivity. 

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