A combination study of spin-trapping, LC/ESR and LC/MS on carbon-centred radicals formed from lipoxygenase-catalysed peroxidation of eicosapentaenoic acid.

@article{Shan2009ACS,
  title={A combination study of spin-trapping, LC/ESR and LC/MS on carbon-centred radicals formed from lipoxygenase-catalysed peroxidation of eicosapentaenoic acid.},
  author={Zhen Shan and Qingfeng Yu and Preeti Purwaha and Bin Guo and Steven Y Qian},
  journal={Free radical research},
  year={2009},
  volume={43 1},
  pages={13-27}
}
Increased evidence from animal and in vitro cellular research indicates that the metabolism of eicosapentaenoic acid (EPA) can inhibit carcinogenesis in many cancers. Free radical-mediated peroxidation is one of many possible mechanisms to which EPA's anti-cancer activity has been attributed. However, no direct evidence has been obtained for the formation of any EPA-derived radicals. In this study, a combination of LC/ESR and LC/MS was used with alpha-[4-pyridyl 1-oxide]-N-tert-butyl nitrone to… CONTINUE READING