A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death.

  title={A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death.},
  author={Liana Georgieva Tsenova and Karen Sokol and Victoria H. Freedman and Gilla Kaplan},
  journal={The Journal of infectious diseases},
  volume={177 6},
Tuberculous meningitis (TBM) is a devastating form of tuberculosis that occurs predominantly in children and in immunocompromised adults. To study the pathogenesis of TBM, a rabbit model of acute mycobacterial central nervous system infection was set up (8-day study). Inoculation of live Mycobacterium bovis Ravenel intracisternally induced leukocytosis (predominantly mononuclear cells), high protein levels, and release of tumor necrosis factor-alpha (TNF-alpha) into the cerebrospinal fluid… CONTINUE READING


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