A combination of statistical and analytical evaluation methods as a new optimization strategy for the quantification of pharmaceutical residues in sewage effluent.

In this study, a new solid-phase microextraction (SPME) method for simultaneous extraction of pharmaceutical compounds with acidic and basic characteristics (ibuprofen, fenoprofen, diclofenac, diazepam and loratadine) from residual water samples is proposed. In this procedure, the extraction is processed using two distinct sample pH values. The extraction… (More)