A combination of nucleoside analogues and a protease inhibitor reduces HIV-1 RNA levels in semen: implications for sexual transmission of HIV infection.

@article{Liuzzi1999ACO,
  title={A combination of nucleoside analogues and a protease inhibitor reduces HIV-1 RNA levels in semen: implications for sexual transmission of HIV infection.},
  author={Giuseppina Liuzzi and Antonio Chirianni and Patrizia Bagnarelli and Massimo Clementi and Marcello Piazza},
  journal={Antiviral therapy},
  year={1999},
  volume={4 2},
  pages={95-9}
}
Direct contact with semen is the major route of sexual acquisition of human immunodeficiency virus (HIV) in homosexual and heterosexual partners of seropositive men. In this study, we show that concentrations of HIV-1 RNA molecules in plasma and semen of seropositive patients are related to the duration and type of antiretroviral agents used in treatment. In patients treated with zidovudine alone, 1, 3 and 6 months after the start of therapy, the mean HIV-1 load in plasma was reduced by 0.57, 0… CONTINUE READING