A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia.

@article{Lin2014ACO,
  title={A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia.},
  author={Erica P Lin and Lili Miles and Elizabeth A Hughes and John C McCann and Charles V Vorhees and John J. McAuliffe and Andreas W. Loepke},
  journal={Anesthesia and analgesia},
  year={2014},
  volume={119 5},
  pages={1158-73}
}
BACKGROUND Infant brain injury from hypoxia-ischemia (HI) can lead to life-long impairment, but protective strategies are lacking. Short-term but not long-term protection has been demonstrated in the Rice-Vannucci neonatal brain ischemia model (RVM) by volatile anesthetic administration before HI, while exposure during HI has not been tested. In the current study, we evaluated a combination of sevoflurane and mild hypothermia as a protective approach during HI, both short- and long-term, by… CONTINUE READING
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