A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition

@inproceedings{Schiffmann2017ACO,
  title={A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition},
  author={L M Schiffmann and M Brunold and M. Liwschitz and Valentin Goede and Sonja Loges and Meredith Wroblewski and Alexander M Quaas and Hakan Alakus and Dirk L. Stippel and Christiane J Bruns and Michael Hallek and Hamid Kashkar and Ulrich T Hacker and Oliver Coutelle},
  booktitle={British Journal of Cancer},
  year={2017}
}
Background:Vascular endothelial growth factor (VEGF)-targeting drugs normalise the tumour vasculature and improve access for chemotherapy. However, excessive VEGF inhibition fails to improve clinical outcome, and successive treatment cycles lead to incremental extracellular matrix (ECM) deposition, which limits perfusion and drug delivery. We show here, that low-dose VEGF inhibition augmented with PDGF-R inhibition leads to superior vascular normalisation without incremental ECM deposition thus… CONTINUE READING
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