A combination of borage seed oil and quercetin reduces fat accumulation and improves insulin sensitivity in obese rats.

  title={A combination of borage seed oil and quercetin reduces fat accumulation and improves insulin sensitivity in obese rats.},
  author={Paula Aranaz and Mar{\'i}a Zabala and Ana Romo-Hualde and David Navarro-Herrera and Miguel L{\'o}pez-Yoldi and Jos{\'e} Luis Vizmanos and J. Alfredo Mart{\'i}nez and Ferm{\'i}n Ignacio Milagro and Carlos Javier Gonz{\'a}lez-Navarro},
  journal={Food \& function},
The metabolic properties of omega-6 fatty acid consumption are being increasingly accepted. We had previously observed that supplementation with a borage seed oil (BSO), as a source of linoleic (18:2n-6; LA) and gamma-linolenic (18:3n-6; GLA) acids, reduces body weight and visceral adiposity and improves insulin sensitivity in a diet-induced obesity model of Wistar rats. Here, it was investigated whether the anti-obesogenic properties of BSO could be maintained in a pre-obese model of rats, and… 
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Borage oil intake by overweight young adults: no effect on metabolic rate; beneficial effects on plasma triglyceride and HDL cholesterol readings.
In overweight young adults with a family history of obesity, borage oil, a source of GLA, did not show promise as a weight control aid, but could help prevent undesirable readings for two blood lipid measures.
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The protective effect of quercetin on retinal inflammation in mice: the involvement of tumor necrosis factor/nuclear factor-κB signaling pathways.
It is suggested that supplementation of quercetin has beneficial effects on the eyes because of its safety, and biological pathway analysis showed that tumor necrosis factor, cytokine, and NF-κB signaling pathways were involved in the anti-inflammatory mechanisms of quERCetin.


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It is demonstrated that supplementation with low doses of cocoa extract supplementation are safe and sufficient to counteract obesity and type-2 diabetes in rats and provide new insights into the potential application of cocoa supplements in the management of the metabolic syndrome.
Freeze-dried strawberry and blueberry attenuates diet-induced obesity and insulin resistance in rats by inhibiting adipogenesis and lipogenesis.
It is hypothesized that supplementation of diet with 6% w/w of a freeze-dried strawberry-blueberry powder (FDSB) could exert beneficial metabolic effects on Wistar rats, and results suggest that FDSB powder might be useful for treatment/prevention of obesity-related diseases.
Borago officinalis seed oil (BSO), a natural source of omega-6 fatty acids, attenuates fat accumulation by activating peroxisomal beta-oxidation both in C. elegans and in diet-induced obese rats.
The effects of omega-6 fatty acids are highly conserved between worms and obesity-induced mammals, so these compounds could be considered to treat or prevent obesity-related disorders.
Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats.
Quercetin treatment attenuated most of the symptoms of metabolic syndrome, including abdominal obesity, cardiovascular remodeling, and NAFLD, with the most likely mechanisms being decreases in oxidative stress and inflammation.
Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha- Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats.
B was more promising in improving lipid profile and liver fat compared to B + T + TC, while the latter was superior in improving MDA and liver histopathology and Fish oil was more efficient than F+TC+T except for TAC and high density lipoprotein cholesterol which were more improved on addition of TC and T.
Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days.
Effect of long-term dietary supplementation of high-gamma-linolenic canola oil versus borage oil on growth, hematology, serum biochemistry, and N-6 fatty acid metabolism in rats.
Overall, long-term feeding with diets containing up to 15% HGCO resulted in no adverse effects on growth, organ weight, hematology and serum biochemistry as compared to the diet containing 15% BO, suggesting that HGCO may be a safe alternative source of GLA.
Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice.
The curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain.