A combination of borage seed oil and quercetin reduces fat accumulation and improves insulin sensitivity in obese rats.

@article{Aranaz2020ACO,
  title={A combination of borage seed oil and quercetin reduces fat accumulation and improves insulin sensitivity in obese rats.},
  author={Paula Aranaz and Mar{\'i}a Zabala and Ana Romo-Hualde and David Navarro-Herrera and Miguel L{\'o}pez-Yoldi and Jos{\'e} Luis Vizmanos and J. Alfredo Mart{\'i}nez and Ferm{\'i}n Ignacio Milagro and Carlos Javier Gonz{\'a}lez-Navarro},
  journal={Food \& function},
  year={2020}
}
The metabolic properties of omega-6 fatty acid consumption are being increasingly accepted. We had previously observed that supplementation with a borage seed oil (BSO), as a source of linoleic (18:2n-6; LA) and gamma-linolenic (18:3n-6; GLA) acids, reduces body weight and visceral adiposity and improves insulin sensitivity in a diet-induced obesity model of Wistar rats. Here, it was investigated whether the anti-obesogenic properties of BSO could be maintained in a pre-obese model of rats, and… 
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The present work described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them, and described the molecular mechanisms underlying the metabolic impact in obesity and obesity-related diseases.
Borage oil intake by overweight young adults: no effect on metabolic rate; beneficial effects on plasma triglyceride and HDL cholesterol readings.
TLDR
In overweight young adults with a family history of obesity, borage oil, a source of GLA, did not show promise as a weight control aid, but could help prevent undesirable readings for two blood lipid measures.
The roles of quercetin in diabetes mellitus and related metabolic disorders; special focus on the modulation of gut microbiota: A comprehensive review.
TLDR
Findings showed that quercetin can be an effective component for improving glycemic status and other metabolic disorders related to diabetes mellitus based on In vitro and animal studies, however, environmental factors, food processing and using nanoformulations can affect its efficacy in human studies.
The protective effect of quercetin on retinal inflammation in mice: the involvement of tumor necrosis factor/nuclear factor-κB signaling pathways.
TLDR
It is suggested that supplementation of quercetin has beneficial effects on the eyes because of its safety, and biological pathway analysis showed that tumor necrosis factor, cytokine, and NF-κB signaling pathways were involved in the anti-inflammatory mechanisms of quERCetin.

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