A combination of a microemulsion and a phospholipid complex for topical delivery of oxymatrine.

@article{Cao2011ACO,
  title={A combination of a microemulsion and a phospholipid complex for topical delivery of oxymatrine.},
  author={Fa-Hao Cao and W Ouyang and Yan-ping Wang and Peng-fei Yue and S Li},
  journal={Archives of pharmacal research},
  year={2011},
  volume={34 4},
  pages={551-62}
}
Oxymatrine (OMT), a water-soluble drug, has a very low oral bioavailability because of its low membrane permeability and its biotransformation in the gastrointestinal tract. Formulated as an oxymatrine-phospholipid complex (OMT-PLC) can improve the lipid solubility and effectiveness of OMT. The purpose of this study was to explore the utility of the combination of a microemulsion and an OMT-PLC as a topical delivery vehicle for enhancing the absorption and efficacy of OMT. The solubility of OMT… CONTINUE READING
6 Citations
36 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…