A combination of MEF3 and NFI proteins activates transcription in a subset of fast-twitch muscles.

@article{Spitz1997ACO,
  title={A combination of MEF3 and NFI proteins activates transcription in a subset of fast-twitch muscles.},
  author={François Spitz and Marjo Salminen and Josiane Demignon and A. Pierre Kahn and Dominique Daegelen and Pascal Maire},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 2},
  pages={
          656-66
        }
}
The human aldolase A pM promoter is active in fast-twitch muscles. To understand the role of the different transcription factors which bind to this promoter and determine which ones are responsible for its restricted pattern of expression, we analyzed several transgenic lines harboring different combinations of pM regulatory elements. We show that muscle-specific expression can be achieved without any binding sites for the myogenic factors MyoD and MEF2 and that a 64-bp fragment comprising a… CONTINUE READING

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