A combination of IFN-β and temozolomide in human glioma xenograft models: implication of p53-mediated MGMT downregulation

Abstract

Methylation of the O6-methyguanine-DNA methyltransferase (MGMT) gene promoter in gliomas has been reported to be a useful predictor of the responsiveness to temozolomide (TMZ). In our previous experiments, we observed that IFN-β sensitized TMZ-resistant glioma cells with the unmethylated MGMT promoter and that the mechanism of action was possibly due to… (More)
DOI: 10.1007/s00280-007-0520-x

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@article{Natsume2007ACO, title={A combination of IFN-β and temozolomide in human glioma xenograft models: implication of p53-mediated MGMT downregulation}, author={Atsushi Natsume and Toshihiko Wakabayashi and Dai Ishii and Hideharu Maruta and Masazumi Fujii and Shinji Shimato and Motokazu Ito and Jun Yoshida}, journal={Cancer Chemotherapy and Pharmacology}, year={2007}, volume={61}, pages={653-659} }