A combination of HPLC and automated data analysis for monitoring the efficiency of high-pressure homogenization

@inproceedings{Eggenreich2017ACO,
  title={A combination of HPLC and automated data analysis for monitoring the efficiency of high-pressure homogenization},
  author={Britta Eggenreich and Vignesh Rajamanickam and David J. Wurm and Jens Fricke and Christoph Herwig and Oliver Spadiut},
  booktitle={Microbial cell factories},
  year={2017}
}
BACKGROUND Cell disruption is a key unit operation to make valuable, intracellular target products accessible for further downstream unit operations. Independent of the applied cell disruption method, each cell disruption process must be evaluated with respect to disruption efficiency and potential product loss. Current state-of-the-art methods, like measuring the total amount of released protein and plating-out assays, are usually time-delayed and involve manual intervention making them error… CONTINUE READING
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