A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.

@article{Khalil1990ACO,
  title={A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.},
  author={Ismail S. Khalil and L. d'Auriol and M. Gobet and L. Morin and V. Lepage and I. Deschamps and M. S. Park and L. Degos and F. Galibert and J. Hors},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={85 4},
  pages={
          1315-9
        }
}
  • Ismail S. Khalil, L. d'Auriol, +7 authors J. Hors
  • Published 1990
  • Medicine, Biology
  • The Journal of clinical investigation
  • Family and population studies indicate that predisposition to insulin-dependent (type I) diabetes mellitus (IDDM) is polygenic. It has been shown that the absence of the aspartic acid in position 57 (Asp57) of the DQ beta chain is positively correlated to IDDM. However, Asp57-negative haplotypes do not always confer susceptibility and conversely, some Asp57-positive haplotypes seem to be disease associated. It has been suggested that other HLA class II sequences, probably belonging to the HLA… CONTINUE READING
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