A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice.

@article{Fukuyama2011ACO,
  title={A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice.},
  author={Yoshiko Fukuyama and Janice D. King and Kosuke Kataoka and Ryoki Kobayashi and Rebekah S. Gilbert and Susan K. Hollingshead and David E. Briles and Kohtaro Fujihashi},
  journal={Journal of immunology},
  year={2011},
  volume={186 4},
  pages={2454-61}
}
Our previous study showed that a combination of a plasmid-expressing Flt3 ligand (pFL) and CpG oligodeoxynucleotides (CpG ODN) as a combined nasal adjuvant elicited mucosal immune responses in aged (2-y-old) mice. In this study, we investigated whether a combination of pFL and CpG ODN as a nasal adjuvant for a pneumococcal surface protein A (PspA) would enhance PspA-specific secretory-IgA Ab responses, which could provide protective mucosal immunity against Streptococcus pneumoniae infection in… CONTINUE READING
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