A colorectal cancer classification system that associates cellular phenotype and responses to therapy

@article{Sadanandam2013ACC,
  title={A colorectal cancer classification system that associates cellular phenotype and responses to therapy},
  author={A. Sadanandam and C. Lyssiotis and K. Homicsko and E. Collisson and W. J. Gibb and S. Wullschleger and L. Ostos and William A. Lannon and C. Grotzinger and M. D. Rio and B. Lhermitte and A. Olshen and B. Wiedenmann and L. Cantley and J. Gray and D. Hanahan},
  journal={Nature Medicine},
  year={2013},
  volume={19},
  pages={619-625}
}
Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth factor receptor–targeted drug cetuximab in 80 patients. The results of these studies… Expand
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications.
The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers
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