A collagen-targeted biomimetic RGD peptide to promote osteogenesis.

  title={A collagen-targeted biomimetic RGD peptide to promote osteogenesis.},
  author={Rick Visser and Pilar M Arrabal and Leonor Santos-Ruiz and Ra{\'u}l Fern{\'a}ndez-Barranco and Jos{\'e} Becerra and Manuel Cifuentes},
  journal={Tissue engineering. Part A},
  volume={20 1-2},
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of BMPs in combination with collagen type I formulations have to be used for clinical applications. Although integrin-binding arginine-glycine-aspartic acid (RGD) biomimetic peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to… CONTINUE READING