• DOI:10.1016/j.msec.2019.110276
Corpus ID: 208748714

A collagen mimetic peptide-modified hyaluronic acid hydrogel system with enzymatically mediated degradation for mesenchymal stem cell differentiation.

@article{Ren2020ACM,
  title={A collagen mimetic peptide-modified hyaluronic acid hydrogel system with enzymatically mediated degradation for mesenchymal stem cell differentiation.},
  author={Ying Ren and H. Zhang and Wenjuan Qin and B. Du and Ling-rong Liu and Jing Yang},
  journal={Materials science & engineering. C, Materials for biological applications},
  year={2020},
  volume={108},
  pages={
          110276
        }
}

Ying Ren, H. Zhang, +3 authors Jing Yang

Published 2020

Materials Science, Medicine

Materials science & engineering. C, Materials for biological applications

We have successfully designed and synthesized a biomimetic hydrogel system with maleimide-modified hyaluronic acid (HA) as the backbone and conjugated it to the collagen mimetic peptide (GPO)8-CG-RGDS. The matrix metalloproteinase (MMP)-sensitive peptide GCRDGPQGI↓WGQDRCG was the cross-linker. HA has high biocompatibility, low immunogenicity, and the capacity to interact with extracellular molecules. Recent studies have found that matrix metalloproteinases (MMPs) are involved in regulating the… CONTINUE READING

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