A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: objectives, design and methods.


The thyroid gland in children is one of the organs that is most sensitive to external exposure to X and gamma rays. However, data on the risk of thyroid cancer in children after exposure to radioactive iodines are sparse. The Chornobyl accident in Ukraine in 1986 led to the exposure of large populations to radioactive iodines, particularly (131)I. This paper describes an ongoing cohort study being conducted in Belarus and Ukraine that includes 25,161 subjects under the age of 18 years in 1986 who are being screened for thyroid diseases every 2 years. Individual thyroid doses are being estimated for all study subjects based on measurement of the radioactivity of the thyroid gland made in 1986 together with a radioecological model and interview data. Approximately 100 histologically confirmed thyroid cancers were detected as a consequence of the first round of screening. The data will enable fitting appropriate dose-response models, which are important in both radiation epidemiology and public health for prediction of risks from exposure to radioactive iodines from medical sources and any future nuclear accidents. Plans are to continue to follow-up the cohort for at least three screening cycles, which will lead to more precise estimates of risk.

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@article{Stezhko2004ACS, title={A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: objectives, design and methods.}, author={Valentin A Stezhko and Elena E Buglova and Larissa I Danilova and Valentina M Drozd and Nikolaj A Krysenko and Nadia R Lesnikova and Victor F Minenko and Vladislav A Ostapenko and Sergey V Petrenko and Olga N Polyanskaya and Valery A Rzheutski and Mykola D Tronko and Olga O Bobylyova and Tetyana I Bogdanova and Ovsiy V Ephstein and Iryna A Kairo and Olexander V Kostin and Ilya A Likhtarev and Valentin V Markov and Valery A Oliynik and Viktor M Shpak and Valeriy P Tereshchenko and Galina A Zamotayeva and Gilbert W Beebe and Andre C Bouville and Aaron B Brill and John D Burch and Daniel J Fink and Ellen Greenebaum and Geoffrey R Howe and Nickolas K Luckyanov and Ihor J Masnyk and Robert J McConnell and Jacob Robbins and Terry L Thomas and Paul G Voillequ{\'e} and Lydia B Zablotska}, journal={Radiation research}, year={2004}, volume={161 4}, pages={481-92} }