A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance.

@article{Grosen2010ACS,
  title={A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance.},
  author={Dorthe Grosen and C{\'e}cile Chevrier and Axel E Skytthe and Camilla Bille and Kirsten M\olsted and {\AA}se Sivertsen and Jeffrey C Murray and Kaare Christensen},
  journal={Journal of medical genetics},
  year={2010},
  volume={47 3},
  pages={162-8}
}
OBJECTIVES To determine if the anatomical severity of oral clefting affects familial recurrence in a large population based sample. To provide reliable recurrence risk estimates for oral cleft for first, second, and third degree relatives. DESIGN Population based cohort study. SETTING Denmark. PARTICIPANTS 6776 individuals affected with an oral cleft born from 1952 to 2005 and 54 229 relatives. MAIN OUTCOME MEASURES Recurrence risk estimates for oral cleft for first, second, and third… CONTINUE READING