A cohort incidence study of workers exposed to perfluorooctanoic acid (PFOA)

@article{Steenland2015ACI,
  title={A cohort incidence study of workers exposed to perfluorooctanoic acid (PFOA)},
  author={Kyle Steenland and Liping Zhao and Andrea Winquist},
  journal={Occupational and Environmental Medicine},
  year={2015},
  volume={72},
  pages={373 - 380}
}
Objectives Determine if perfluorooctanoic acid (PFOA) is associated with an incident disease in an occupational cohort. Methods We interviewed 3713 workers or their next of kin in 2008–2011, and sought medical records for self-reported disease. These workers were a subset of a previously studied cohort of 32 254 community residents and workers. We estimated historical PFOA serum levels via a job-exposure matrix based on over 2000 serum measurements. Non-occupational exposure from drinking water… 

Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community

Modeled perfluorooctanoic acid exposure and liver function in a Mid-Ohio Valley community is consistent with previous cross-sectional studies showing association between PFOA and ALT, a marker of hepatocellular damage.

Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community.

Association Between PFOA Exposure and Liver Enzymes: a Systematic Review and Meta-analysis of Longitudinal Cohort Studies

The hypothesis that PFOA increases levels of four common liver enzymes, and that this causal relationship was observed within the context of a population-based study area, is supported.

Perfluorooctanoate and Perfluorooctanesulfonate plasma concentrations and survival after prostate and bladder cancer in a population-based study

The results of the present study does not suggest an association between PFOA or PFOS concentrations and survival among prostate cancer patients, but they may be inversely associated with both overall and bladder cancer–specific mortality in bladder cancer patients.

Prostate Cancer and PFOA.

This letter is offered to identify important additional information that was not addressed in two articles published in Journal of Occupational and Environmental Medicine that have examined issues surrounding prostate cancer and PFOA.
...

References

SHOWING 1-10 OF 34 REFERENCES

Cohort mortality study of workers exposed to perfluorooctanoic acid.

Evidence of positive exposure-response trends for malignant and nonmalignant renal disease is found in a cohort of 5,791 workers exposed to PFOA at a DuPont chemical plant in West Virginia from 1979-2004.

Ulcerative Colitis and Perfluorooctanoic Acid (PFOA) in a Highly Exposed Population of Community Residents and Workers in the Mid-Ohio Valley

Evidence is found that PFOA is associated with ulcerative colitis, the first study of associations between this common environmental exposure and autoimmune diseases in humans.

Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant

PFOA exposure was associated with kidney and testicular cancer in this population of Mid-Ohio Valley residents, and findings must be interpreted with caution, especially for highly fatal cancers such as pancreatic and lung cancer.

Retrospective exposure assessment of perfluorooctanoic acid serum concentrations at a fluoropolymer manufacturing plant.

Estimates of serum PFOA for the worker cohort were developed for the period of 1950-2004 using linear mixed models to account for repeated measures, along with exposure determinants such as cumulative years worked in potentially exposed jobs to reflect the influence of process changes over calendar time on exposure.

Perfluorooctanoic Acid Exposure and Thyroid Disease in Community and Worker Cohorts

Higher PFOA exposure was associated with incident functional thyroid disease in this large cohort with high exposure, and some subanalyses also suggested an increased hazard of hypothyroidism among men.

Perfluorooctanoic Acid Exposure and Cancer Outcomes in a Contaminated Community: A Geographic Analysis

Higher PFOA serum levels may be associated with testicular, kidney, prostate, and ovarian cancers and non-Hodgkin lymphoma among residents living near the DuPont Teflon-manufacturing plant in Parkersburg, West Virginia.

Ammonium Perfluorooctanoate Production and Occupational Mortality

Exposure to ammonium perfluorooctanoate exposure was not associated with liver, pancreatic or testicular cancer or with cirrhosis of the liver, and exposure was associated (albeit inconsistently) with prostate cancer, cerebrovascular disease, and diabetes.

Mortality and cancer incidence in ammonium perfluorooctanoate production workers

This analysis did not support an association between occupational APFO exposure and the evaluated health endpoints, however, the study had limited power to evaluate some conditions of interest.