A coherent biochemical basis for increased reactivity to contrast material in allergic patients: a novel concept.

@article{Lasser1987ACB,
  title={A coherent biochemical basis for increased reactivity to contrast material in allergic patients: a novel concept.},
  author={Elliott C. Lasser},
  journal={AJR. American journal of roentgenology},
  year={1987},
  volume={149 6},
  pages={
          1281-5
        }
}
  • E. Lasser
  • Published 1 December 1987
  • Medicine
  • AJR. American journal of roentgenology
Bradykinin, the end product of activation of the plasma contact system, may play a significant role in reactions to contrast material and in other forms of anaphylactoid and anaphylactic responses to drugs or antigens. Activation of factor XII initiates activity in the plasma contact system, and we have identified factors (negatively charged surfaces) present in elevated concentrations in the plasma of patients who are asthmatic or allergic that can "prime" their plasma for the initiation and… 

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  • S. Morcos
  • Medicine
    The British journal of radiology
  • 2005
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References

SHOWING 1-10 OF 20 REFERENCES

Basic mechanisms of contrast media reactions. Theoretical and experimental considerations.

In a broad sense the basic mechanisms that underlie reactions to injections of roentgen contrast media can be considered in two major categories: (a) allergic or idiosyncratic and (b) chemotoxic. It

Kinin Activation as a Predictive Assay for Adverse Reactions to Radiographic Contrast Medium

This retrospective investigation suggests that prekallikrein/kallIKrein conversion rate may form the basis of a test for differentiating between reactors and non-reactors.

Molecular markers of contrast media-induced adverse reactions.

Currently used routine laboratory screening methods are not reliable in the prediction of contrast media-related adverse reactions. Cost-effective laboratory methods for various molecular markers of

The plasma contact system in atopic asthma.

Heparin‐like anticoagulants in asthma

It is found that the baseline plasma samples of patients with asthma contain average levels of an endogenous heparin‐like material (EHM) that is significantly higher than that noted in non‐allergic, non‐asthmatic controls.

Microvascular heparin-like species with anticoagulant activity.

The anticoagulant activity of this preparation is most probably associated with both endothelial cells and mast cells, however, complete separation of these two cellular elements has proven difficult with current methodology.

Epidemiologic and socioeconomic aspects of allergic diseases.

Immediate skin-test reactivity in a general population sample.

The prick test was judged to be a useful tool for the assessment of atopy, and reactions tended to be multiple, highly reproducible, and more frequent among those in the higher socioeconomic strata.

The Current Status of Reactions to Intravenous Contrast Media

A prospective 12-month survey in 272 United Kingdom hospitals was performed and data are presented on the incidence of adverse reactions following intravenous urography, contrast CT scanning, and