A coherent biochemical basis for increased reactivity to contrast material in allergic patients: a novel concept.

  title={A coherent biochemical basis for increased reactivity to contrast material in allergic patients: a novel concept.},
  author={Elliott C. Lasser},
  journal={AJR. American journal of roentgenology},
  volume={149 6},
  • E. Lasser
  • Published 1 December 1987
  • Medicine
  • AJR. American journal of roentgenology
Bradykinin, the end product of activation of the plasma contact system, may play a significant role in reactions to contrast material and in other forms of anaphylactoid and anaphylactic responses to drugs or antigens. Activation of factor XII initiates activity in the plasma contact system, and we have identified factors (negatively charged surfaces) present in elevated concentrations in the plasma of patients who are asthmatic or allergic that can "prime" their plasma for the initiation and… 

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Review article: Acute serious and fatal reactions to contrast media: our current understanding.

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  • 2005
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