A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.

@article{Xiao1998ACT,
  title={A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.},
  author={Hong Xiao and Yumin Tao and Jack Greenblatt and Robert G Roeder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 5},
  pages={
          2146-51
        }
}
Replication of HIV-1 requires the viral Tat protein, which increases the extent of transcription elongation by RNA polymerase II after activation at the single viral long terminal repeat (LTR) promoter. This effect of Tat on transcription requires Tat interactions with a 5' region (TAR) in nascent transcripts as well as Tat-specific cofactors. The present study identifies a cellular protein, TIP30, that interacts with Tat and with an SRB-containing RNA polymerase II complex both in vivo and in… CONTINUE READING

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