A codon change in beta-tubulin which drastically affects microtubule structure in Drosophila melanogaster fails to produce a significant phenotype in Saccharomyces cerevisiae.

@article{Praitis1991ACC,
  title={A codon change in beta-tubulin which drastically affects microtubule structure in Drosophila melanogaster fails to produce a significant phenotype in Saccharomyces cerevisiae.},
  author={Vida Praitis and Wendy S. Katz and Frank Solomon},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 9},
  pages={
          4726-31
        }
}
  • Vida Praitis, Wendy S. Katz, Frank Solomon
  • Published in
    Molecular and cellular…
    1991
  • Biology, Medicine
  • The relative uniformity of microtubule ultrastructure in almost all eukaryotic cells is thought to be a consequence of the conserved elements of tubulin sequence. In support of this idea, a mutation in a beta-tubulin gene of Drosophila melanogaster, occurring at a highly conserved position, produces U-shaped microtubules, suggesting a defect in either nucleation or packing during assembly (M. T. Fuller, J. H. Caulton, J. A. Hutchens, T. C. Kaufman, and E. C. Raff, J. Cell Biol. 104:385-394… CONTINUE READING

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