A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

@inproceedings{Timmons2018ACA,
  title={A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease},
  author={James A. Timmons and Philip J Atherton and O Larsson and Sanjana Sood and Ilya O. Blokhin and Robert J. Brogan and Claude-Henry Volmar and Andrea R. Josse and Cris A. Slentz and Claes Wahlestedt and Stuart M Phillips and Bethan E. Phillips and Iain J. Gallagher and William E Kraus},
  booktitle={Nucleic acids research},
  year={2018}
}
Genome-wide association studies (GWAS), relying on hundreds of thousands of individuals, have revealed >200 genomic loci linked to metabolic disease (MD). Loss of insulin sensitivity (IS) is a key component of MD and we hypothesized that discovery of a robust IS transcriptome would help reveal the underlying genomic structure of MD. Using 1,012 human skeletal muscle samples, detailed physiology and a tissue-optimized approach for the quantification of coding (>18,000) and non-coding (>15,000… CONTINUE READING
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